Review: Mitochondrial Defects in Breast Cancer | Zendy

Josefa Salgado | Zendy; Beatriz Honorato | Zendy; Jesús GarcíaFoncillas | Zendy

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Review: Mitochondrial Defects in Breast Cancer

Author(s) -

Josefa Salgado,

Beatriz Honorato,

Jesús GarcíaFoncillas

Publication year - 2008

Publication title -

clinical medicine oncology

Language(s) - English

Resource type - Journals

ISSN - 1177-9314

DOI - 10.4137/cmo.s524

Subject(s) - mitochondrial dna , breast cancer , carcinogenesis , nuclear dna , mitochondrion , medicine , cancer , dna damage , cancer research , dna repair , dna , apoptosis , genetics , bioinformatics , biology , gene

Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Mitochondrial DNA has been proposed to be involved in carcinogenesis because of its high susceptibility to mutations and limited repair mechanisms in comparison to nuclear DNA. Breast cancer is the most frequent cancer type among women in the world and, although exhaustive research has been done on nuclear DNA changes, several studies describe a variety of mitochondrial DNA alterations present in breast cancer. In this review article, we to provide a summary of the mitochondrial genomic alterations reported in breast cancer and their functional consequences.

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