Galectin-3 as a Potential Target to Prevent Cancer Metastasis | Zendy

Hafiz Ahmed | Zendy; Dina M.M. AlSadek | Zendy

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Galectin-3 as a Potential Target to Prevent Cancer Metastasis

Author(s) -

Hafiz Ahmed,

Dina M.M. AlSadek

Publication year - 2015

Publication title -

clinical medicine insights oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 26

ISSN - 1179-5549

DOI - 10.4137/cmo.s29462

Subject(s) - galectin 3 , galectin , metastasis , carcinogenesis , extracellular matrix , cancer research , immune system , lectin , cancer , biology , microbiology and biotechnology , cancer cell , function (biology) , chemistry , immunology , genetics

Interactions between two cells or between cell and extracellular matrix mediated by protein-carbohydrate interactions play pivotal roles in modulating various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding lectin family, is involved in fibrosis as well as cancer progression and metastasis, but the detailed mechanisms of its functions remain elusive. This review discusses its structure, carbohydrate-binding properties, and involvement in various aspects of tumorigenesis and some potential carbohydrate ligands that are currently investigated to block galectin-3 activity.

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