Case Report about Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test | Zendy

B. Dupont | Zendy; Delphine Mariotte | Zendy; Cristian Moldovan | Zendy; JeanMichel Grellard | Zendy; M Vergnaud | Zendy; D. Laroche | Zendy; Radj Gervais | Zendy

Open Access

Case Report about Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test

Author(s) -

B. Dupont,

Delphine Mariotte,

Cristian Moldovan,

JeanMichel Grellard,

M Vergnaud,

D. Laroche,

Radj Gervais

Publication year - 2014

Publication title -

clinical medicine insights oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 26

ISSN - 1179-5549

DOI - 10.4137/cmo.s13897

Subject(s) - cetuximab , medicine , immunoglobulin e , hypersensitivity reaction , antibody , immunology , monoclonal antibody

Hypersensitivity reactions are a classic side effect of cetuximab. We report the cases of three patients who developed life-threatening hypersensitivity to cetuximab, which could have been predicted by assessing the concentration of serum anticetuximab immunoglobulin (Ig)E. The anticetuximab IgE concentration could be an interesting test to predict which patients are at risk of experiencing severe hypersensitivity reactions to cetuximab.

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