β3-Adrenoceptor Antagonist SR59230A Attenuates the Imbalance of Systemic and Myocardial Oxygen Transport Induced by Dopamine in Newborn Lambs | Zendy

Richdeep S. Gill | Zendy; Po-Yin Cheun | Zendy; Xiaoyang Yu | Zendy; Mohammed Al Aklabi | Zendy; Jeevan Nagendran | Zendy; Luis G. Quiñonez | Zendy; Ying Qian Li | Zendy; John A. Miller | Zendy; David B. Ross | Zendy; Ivan M. Rebeyka | Zendy; Jia Li | Zendy

Open Access

β₃-Adrenoceptor Antagonist SR59230A Attenuates the Imbalance of Systemic and Myocardial Oxygen Transport Induced by Dopamine in Newborn Lambs

Author(s) -

Richdeep S. Gill,

Po-Yin Cheun,

Xiaoyang Yu,

Mohammed Al Aklabi,

Jeevan Nagendran,

Luis G. Quiñonez,

Ying Qian Li,

John A. Miller,

David B. Ross,

Ivan M. Rebeyka,

Jia Li

Publication year - 2012

Publication title -

clinical medicine insights cardiology

Language(s) - English

Resource type - Journals

ISSN - 1179-5468

DOI - 10.4137/cmc.s8654

Subject(s) - heart rate , medicine , dopamine , chemistry , endocrinology , anesthesia , blood pressure

In neonates, the increase in O(2)-delivery (DO(2)) by dopamine is offset by a greater increase in O(2)-consumption (VO(2)). This has been attributed to β(3)-adrenergic receptors in neonatal brown fat tissue. β(3) receptors in the heart have negative inotropic properties. We evaluated the effects of SR59230A, a β(3)-antagonist, on the balance of systemic and myocardial O(2)-transport in newborn lambs treated with dopamine.

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