Methods for Detection of Matrix Metalloproteinases as Biomarkers in Cardiovascular Disease | Zendy

Viorica LopezAvila | Zendy; Juliet V. Spencer | Zendy

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Methods for Detection of Matrix Metalloproteinases as Biomarkers in Cardiovascular Disease

Author(s) -

Viorica LopezAvila,

Juliet V. Spencer

Publication year - 2008

Publication title -

clinical medicine cardiology

Language(s) - English

Resource type - Journals

ISSN - 1178-1165

DOI - 10.4137/cmc.s484

Subject(s) - matrix metalloproteinase , extracellular matrix , fibronectin , laminin , myocardial infarction , medicine , morphogenesis , proteolytic enzymes , heart failure , microbiology and biotechnology , pathology , biology , cardiology , enzyme , biochemistry , gene

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that degrade extracellular matrix (ECM) components like collagen, fibronectin, and laminin. While this activity is important for normal development, morphogenesis, and wound healing, deregulation of MMP activity has been implicated in a number of cardiovascular diseases, including congenital heart defects, atherosclerosis, myocardial infarction, and congestive heart failure. MMPs are good potential diagnostic indicators of cardiovascular disease, but current detection methods are time consuming and quite laborious. This review will discuss MMP biology, current methods for detection of MMPs from patient samples, and potential new developments in multiplexed analysis of MMPs.

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