Q192R Paraoxonase (PON)1 Polymorphism, Insulin Sensitivity, and Endothelial Function in Essential Hypertensive Men | Zendy

Giulia Dell’Omo | Zendy; Giuseppe Penno | Zendy; Laura Pucci | Zendy; Daniela Lucchesi | Zendy; Stefano Del Prato | Zendy; Roberto Pedrinelli | Zendy

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Q192R Paraoxonase (PON)1 Polymorphism, Insulin Sensitivity, and Endothelial Function in Essential Hypertensive Men

Author(s) -

Giulia Dell’Omo,

Giuseppe Penno,

Laura Pucci,

Daniela Lucchesi,

Stefano Del Prato,

Roberto Pedrinelli

Publication year - 2014

Publication title -

clinical medicine insights cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 21

ISSN - 1179-5468

DOI - 10.4137/cmc.s15493

Subject(s) - medicine , insulin resistance , endocrinology , essential hypertension , endothelial dysfunction , paraoxonase , insulin , homeostatic model assessment , blood pressure , biology , oxidative stress

Essential hypertension is characterized by increased reactive oxygen species (ROS) generation harmful for insulin sensitivity and nitric oxide (NO)-mediated vasomotor function, a noxious effect that paraoxonase (PON)1, an antioxidant circulating high-density lipoprotein (HDL)-bound esterase, may counteract. The PON1 gene contains several polymorphisms including a glutamine (Q) to arginine (R) transition at position 192 encoding circulating allozymes with higher antioxidant activity that might influence both parameters.

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