Atrial Natriuretic Peptide Single Nucleotide Polymorphisms in Patients with Nonfamilial Structural Atrial Fibrillation | Zendy

Pietro Francia | Zendy; Agnese Ricotta | Zendy; Alessandra Frattari | Zendy; Rosita Stanzione | Zendy; Anna Modestino | Zendy; Federico Mercanti | Zendy; Carmen Adduci | Zendy; Isabella Sensini | Zendy; Maria Cotugno | Zendy; Cristina Balla | Zendy; Speranza Rubattu | Zendy; Massimo Volpe | Zendy

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Atrial Natriuretic Peptide Single Nucleotide Polymorphisms in Patients with Nonfamilial Structural Atrial Fibrillation

Author(s) -

Pietro Francia,

Agnese Ricotta,

Alessandra Frattari,

Rosita Stanzione,

Anna Modestino,

Federico Mercanti,

Carmen Adduci,

Isabella Sensini,

Maria Cotugno,

Cristina Balla,

Speranza Rubattu,

Massimo Volpe

Publication year - 2013

Publication title -

clinical medicine insights cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 21

ISSN - 1179-5468

DOI - 10.4137/cmc.s12239

Subject(s) - medicine , atrial natriuretic peptide , single nucleotide polymorphism , atrial fibrillation , cardiology , odds ratio , population , myocardial infarction , case control study , endocrinology , genotype , genetics , biology , gene , environmental health

Atrial natriuretic peptide (ANP) has antihypertrophic and antifibrotic properties that are relevant to AF substrates. The -G664C and rs5065 ANP single nucleotide polymorphisms (SNP) have been described in association with clinical phenotypes, including hypertension and left ventricular hypertrophy. A recent study assessed the association of early AF and rs5065 SNPs in low-risk subjects. In a Caucasian population with moderate-to-high cardiovascular risk profile and structural AF, we conducted a case-control study to assess whether the ANP -G664C and rs5065 SNP associate with nonfamilial structural AF.

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