Lack of Influence of the Androgen Receptor Gene CAG-Repeat Polymorphism on Clinical and Electrocardiographic Manifestations of the Brugada Syndrome in Man | Zendy

Stefania Mariani | Zendy; Beatrice Musumeci | Zendy; Sabrina Basciani | Zendy; Daniela Fiore | Zendy; Pietro Francia | Zendy; Agnese Persichetti | Zendy; Massimo Volpe | Zendy; Camillo Autore | Zendy; Costanzo Moretti | Zendy; Salvatore Ulisse | Zendy; Lucio Gnessi | Zendy

Open Access

Lack of Influence of the Androgen Receptor Gene CAG-Repeat Polymorphism on Clinical and Electrocardiographic Manifestations of the Brugada Syndrome in Man

Author(s) -

Stefania Mariani,

Beatrice Musumeci,

Sabrina Basciani,

Daniela Fiore,

Pietro Francia,

Agnese Persichetti,

Massimo Volpe,

Camillo Autore,

Costanzo Moretti,

Salvatore Ulisse,

Lucio Gnessi

Publication year - 2012

Publication title -

clinical medicine insights cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 21

ISSN - 1179-5468

DOI - 10.4137/cmc.s10553

Subject(s) - brugada syndrome , androgen receptor , polymorphism (computer science) , gene , medicine , genetics , endocrinology , biology , genotype , prostate cancer , cancer

Clinical studies suggest that testosterone (T) plays an important role in the male predominance of the clinical manifestations of the Brugada syndrome (BS). However, no statistically significant correlations have been observed between T levels and electrocardiogram (ECG) parameters in the BS patients. We investigated whether the hormonal pattern and the variation within CAG repeat polymorphism in exon 1 of the androgen receptor (AR) gene, affecting androgen sensitivity, are associated with the Brugada ECG phenotype in males.

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