Long Term Results after 3 Courses of ABVD plus Subtotal Nodal Radiotherapy in 188 Adult Patients with Stage I, II and IIIA Hodgin Lymphoma | Zendy

Pauline Brice | Zendy; Marc André | Zendy; Patricia Franchi-Rezgui | Zendy; Irène Biasoli | Zendy; Christophe Hennequin | Zendy

Open Access

Long Term Results after 3 Courses of ABVD plus Subtotal Nodal Radiotherapy in 188 Adult Patients with Stage I, II and IIIA Hodgin Lymphoma

Author(s) -

Pauline Brice,

Marc André,

Patricia Franchi-Rezgui,

Irène Biasoli,

Christophe Hennequin

Publication year - 2008

Publication title -

clinical medicine blood disorders

Language(s) - English

Resource type - Journals

ISSN - 1178-2269

DOI - 10.4137/cmbd.s357

Subject(s) - medicine , abvd , radiation therapy , stage (stratigraphy) , chemotherapy , lymphoma , surgery , mediastinum , dacarbazine , complete remission , oncology , vincristine , cyclophosphamide , paleontology , biology

In patients with Hodgkin lymphoma (HL) a continued improvement in outcome with a high cure rate is observed but with an increased treatment-induced late effects. We report the long-term results from 188 (stage I to IIIA) patients treated during the period 1985-94 with 3 courses of ABVD-like chemotherapy and subtotal nodal radiotherapy. 10 year overall survival is of 88% and no secondary leukaemia was observed. The main long term toxicity was cardiac, mainly related to a mediastinal dose of 45 Grays in patients with partial remission. New strategies are aiming to reduce the mediastinal dose at 30 Grays after chemotherapy-induced complete remission

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