Open AccessTNF-α and TNF-β Gene Polymorphism in Saudi Rheumatoid Arthritis Patients
Author(s) -
Hannan Al-Rayes,
Ramiz Al-Swailem,
Maysson Albelawi,
Misbahul Arfin,
Abdulrahman Alasmari,
Mohammad Tariq
Publication year - 2011
Publication title -
clinical medicine insights arthritis and musculoskeletal disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.418
H-Index - 21
ISSN - 1179-5441
DOI - 10.4137/cmamd.s6941
Subject(s) - genotype , rheumatoid arthritis , tumor necrosis factor alpha , allele , medicine , immunology , allele frequency , arthritis , gene polymorphism , gene , biology , genetics
Tumor necrosis factor (TNF)-α and -β are cytokines with a wide range of inflammatory, apoptotic and immunomodulatory activities. TNF-α promoter -308 G < A polymorphism has been reported to be associated with rheumatoid arthritis (RA) with inconsistent results.
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