Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker | Zendy

Arianna Filntisi | Zendy; Dimitriοs Vlachakis | Zendy; George K. Matsopoulos | Zendy; Σοφία Κοσσίδα | Zendy

Open Access

Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker

Author(s) -

Arianna Filntisi,

Dimitriοs Vlachakis,

George K. Matsopoulos,

Σοφία Κοσσίδα

Publication year - 2014

Publication title -

cancer informatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.606

H-Index - 31

ISSN - 1176-9351

DOI - 10.4137/cin.s19222

Subject(s) - linker , conjugate , antibody , drug , chemistry , covalent bond , antibody drug conjugate , computational biology , cancer research , medicine , pharmacology , computer science , biology , monoclonal antibody , immunology , mathematical analysis , mathematics , organic chemistry , operating system

Antibody-drug conjugates (ADCs) constitute a category of anticancer targeted therapy that has gathered great interest during the last few years because of their potential to kill cancer cells while causing significantly fewer side effects than traditional chemotherapy. In this paper, a process of computational construction of ADCs is described, using the surface lysines of an antibody and a non-covalent linker molecule, as well as a cytotoxic substance, as files in Protein Data Bank format. Also, aspects related to the function, properties, and development of ADCs are discussed.

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