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New Insight on the Role of Plasminogen Receptor in Cancer Progression
Author(s) -
Seema Kumari,
Rama Rao Malla
Publication year - 2015
Publication title -
cancer growth and metastasis
Language(s) - English
Resource type - Journals
ISSN - 1179-0644
DOI - 10.4137/cgm.s27335
Subject(s) - metastasis , receptor , annexin a2 , cancer research , angiogenesis , biology , gene silencing , cancer cell , microbiology and biotechnology , cancer , cell , annexin , biochemistry , gene , genetics
Plasminogen system plays a crucial role in physiological and pathological events related to tissue regeneration, wound healing, immune response, angiogenesis, invasion and metastasis. It gets activated when plasminogen associates with its cell surface receptors. Latest information on some of the well-explored plasminogen receptors such as annexin II-S100A10, cytokeratin 8, α-enolase, plasminogen receptor (KT) (Plg-R(KT)) and histone H2B has been discussed in the present review. These receptors can pave the way for effective new therapeutic and diagnostic strategies to counteract malignant diseases.

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