Linaclotide: A New Option for the Treatment of Irritable Bowel syndrome with Constipation and Chronic Idiopathic Constipation in Adults | Zendy

Colleen H. Parker | Zendy; Yuhong Yuan | Zendy; Louis Wing Cheong Liu | Zendy

Open Access

Linaclotide: A New Option for the Treatment of Irritable Bowel syndrome with Constipation and Chronic Idiopathic Constipation in Adults

Author(s) -

Colleen H. Parker,

Yuhong Yuan,

Louis Wing Cheong Liu

Publication year - 2013

Publication title -

clinical medicine insights gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.373

H-Index - 11

ISSN - 1179-5522

DOI - 10.4137/cgast.s10550

Subject(s) - irritable bowel syndrome , medicine , gastroenterology , constipation , chronic constipation , cystic fibrosis transmembrane conductance regulator , lubiprostone , cystic fibrosis

Chronic idiopathic constipation (CC) and irritable bowel syndrome with predominant constipation (IBS-C) are the 2 most common conditions among functional gastrointestinal disorders. Despite current multiple therapeutic options, treatment remains challenging and dissatisfactory to many patients. Linaclotide is a novel therapeutic agent, which is a guanylate cyclase receptor agonist that stimulates water secretion from the intestinal epithelium by promoting chloride and bicarbonate efflux into the lumen through activation of the cystic fibrosis transmembrane conductance regulator. Clinical trials have demonstrated that linaclotide is effective, safe and well tolerated in patients with CC and IBS-C. This review article highlights the mechanism of action of linaclotide, reviews published literature based on a search of databases, including MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL), up to February 2013, and compares its utility with other currently available agents.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research