Measurement of CO3-610, a Potential Liver Biomarker Derived from Matrix Metalloproteinase-9 Degradation of Collagen Type III, in a Rat Model of Reversible Carbon-Tetrachloride-Induced Fibrosis | Zendy

Efstathios Vassiliadis | Zendy; Dorthe Vang Larsen | Zendy; Rikke Elgaard Clausen | Zendy; Sanne Skovgård Veidal | Zendy; Natasha Barascuk | Zendy; Lise Larsen | Zendy; Henrik Toft Simonsen | Zendy; Toni Segovia Silvestre | Zendy; C. Hansen | Zendy; Trine Overgaard | Zendy; Diana Julie Leeming | Zendy; M.A. Karsdal | Zendy

Open Access

Measurement of CO3-610, a Potential Liver Biomarker Derived from Matrix Metalloproteinase-9 Degradation of Collagen Type III, in a Rat Model of Reversible Carbon-Tetrachloride-Induced Fibrosis

Author(s) -

Efstathios Vassiliadis,

Dorthe Vang Larsen,

Rikke Elgaard Clausen,

Sanne Skovgård Veidal,

Natasha Barascuk,

Lise Larsen,

Henrik Toft Simonsen,

Toni Segovia Silvestre,

C. Hansen,

Trine Overgaard,

Diana Julie Leeming,

M.A. Karsdal

Publication year - 2011

Publication title -

biomarker insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.075

H-Index - 31

ISSN - 1177-2719

DOI - 10.4137/bmi.s6347

Subject(s) - sirius red , carbon tetrachloride , fibrosis , medicine , biomarker , pathology , ccl4 , type i collagen , histology , histopathology , hydroxyproline , gastroenterology , endocrinology , chemistry , biochemistry , organic chemistry

The current study utilized a carbon tetrachloride (CCl(4))-induced liver fibrosis model to measure levels of the MMP9-mediated collagen type III degradation fragment CO3-610 (site of cleavage: KNGETGPQGP), during disease progression and regression, and to investigate a potential prognostic role of the biomarker.

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