The Role of Thrombospondin 1 on Intestinal Inflammation and Carcinogenesis | Zendy

Linda S. Gutierrez | Zendy

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The Role of Thrombospondin 1 on Intestinal Inflammation and Carcinogenesis

Author(s) -

Linda S. Gutierrez

Publication year - 2008

Publication title -

biomarker insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.075

H-Index - 31

ISSN - 1177-2719

DOI - 10.4137/bmi.s630

Subject(s) - angiogenesis , carcinogenesis , medicine , ulcerative colitis , inflammation , inflammatory bowel disease , colorectal cancer , cancer research , population , thrombospondin 1 , disease , immunology , crohn's disease , cancer , environmental health

Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBD) quite common in the United States and other Western countries. Patients suffering IBD are at greater risk of developing colorectal adenocarcinoma than the general population. Both, the adenoma-carcinoma and the inflammation-carcinogenesis processes are characterized by active angiogenesis. Recent studies also have shown that anti-angiogenesis might be a novel therapeutic approach for IBD. Thrombospondin 1 (TSP1) is an extracellular protein well known for its anti-angiogenic properties. TSP1 also has key functions in inflammation, which is assumed to be the primary cause for carcinogenesis in IBD. This review is focused on the role of TSP1 in colorectal carcinogenesis. The therapeutic effects of TSP derived-peptides on inhibiting the inflammationcarcinogenesis progression are also discussed.

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