Prediction of the Risk for Essential Hypertension among Carriers of C825T Genetic Polymorphism of G Protein β3 (GNB3) Gene | Zendy

Neveen Salah El Din Hemimi | Zendy; Amal Mansour | Zendy; Mona Abdelsalam | Zendy

Open Access

Prediction of the Risk for Essential Hypertension among Carriers of C825T Genetic Polymorphism of G Protein β3 (GNB3) Gene

Author(s) -

Neveen Salah El Din Hemimi,

Amal Mansour,

Mona Abdelsalam

Publication year - 2016

Publication title -

biomarker insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.075

H-Index - 31

ISSN - 1177-2719

DOI - 10.4137/bmi.s38321

Subject(s) - allele , heterotrimeric g protein , odds ratio , essential hypertension , genotype , genetics , single nucleotide polymorphism , medicine , candidate gene , gene , biology , microbiology and biotechnology , g protein , blood pressure , signal transduction

The guanine nucleotide-binding protein beta polypeptide 3 (GNB3) 825T allele encodes a product that enhances the activation of heterotrimeric G proteins, which is associated with the occurrence of the splice variant Gβ3 s that could play a role in vascular reactivity and hyperproliferation of smooth muscle cells, that makes such proteins attractive candidate gene products for susceptibility to essential hypertension (EH).

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