miRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review | Zendy

Alemar Bárbara | Zendy; Gregório Cleandra | Zendy; Ashton-Prolla Patricia | Zendy

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miRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review

Author(s) -

Alemar Bárbara,

Gregório Cleandra,

Ashton-Prolla Patricia

Publication year - 2015

Publication title -

biomarker insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.075

H-Index - 31

ISSN - 1177-2719

DOI - 10.4137/bmi.s27679

Subject(s) - pancreatic ductal adenocarcinoma , medicine , pancreatic cancer , adenocarcinoma , microrna , pathology , disease , cancer , pancreas , oncology , bioinformatics , biology , gene , biochemistry

Pancreatic ductal adenocarcinoma (PDAC), a rare but lethal tumor, is difficult to diagnose without performing an invasive procedure. miRNAs are known to be deregulated in PDAC patients, and recent studies have shown that they can be used as diagnostic and prognostic of the disease. The detection of miRNAs in samples acquired through minimally or noninvasive procedures, such as serum, plasma, and saliva, can have a positive impact on the clinical management of these patients. This article is a comprehensive review of the major studies that have evaluated the expression of miRNAs as biomarkers in pancreatic cancer and its premalignant lesions.

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