Protein Modifications as Potential Biomarkers in Breast Cancer | Zendy

Hongjun Jin | Zendy; Richard C. Zangar | Zendy

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Protein Modifications as Potential Biomarkers in Breast Cancer

Author(s) -

Hongjun Jin,

Richard C. Zangar

Publication year - 2009

Publication title -

biomarker insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.075

H-Index - 31

ISSN - 1177-2719

DOI - 10.4137/bmi.s2557

Subject(s) - breast cancer , tissue microarray , cancer , medicine , posttranslational modification , computational biology , proteomics , cancer research , cancer biomarkers , bioinformatics , biomarker , biology , biochemistry , gene , enzyme

A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.

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