Quantitative Appraisal of Ventricular Cerebrospinal Fluid Biomarkers in Neuropathologically Diagnosed Parkinson's Disease Cases Lacking Alzheimer's Disease Pathology | Zendy

Chera L. Maarouf | Zendy; Thomas G. Beach | Zendy; Charles H. Adler | Zendy; Michael MalekAhmadi | Zendy; Tyler A. Kokjohn | Zendy; Brittany N. Dugger | Zendy; Douglas G. Walker | Zendy; Holly A. Shill | Zendy; Sandra A. Jacobson | Zendy; Marwan N. Sabbagh | Zendy; Alex E. Roher | Zendy

Open Access

Quantitative Appraisal of Ventricular Cerebrospinal Fluid Biomarkers in Neuropathologically Diagnosed Parkinson's Disease Cases Lacking Alzheimer's Disease Pathology

Author(s) -

Chera L. Maarouf,

Thomas G. Beach,

Charles H. Adler,

Michael MalekAhmadi,

Tyler A. Kokjohn,

Brittany N. Dugger,

Douglas G. Walker,

Holly A. Shill,

Sandra A. Jacobson,

Marwan N. Sabbagh,

Alex E. Roher

Publication year - 2013

Publication title -

biomarker insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.075

H-Index - 31

ISSN - 1177-2719

DOI - 10.4137/bmi.s11422

Subject(s) - neuropathology , cerebrospinal fluid , medicine , pathology , odds ratio , disease , confidence interval , parkinson's disease , biomarker , alzheimer's disease , biology , biochemistry

Identifying biomarkers that distinguish Parkinson's disease (PD) from normal control (NC) individuals has the potential to increase diagnostic sensitivity for the detection of early-stage PD. A previous proteomic study identified potential biomarkers in postmortem ventricular cerebrospinal fluid (V-CSF) from neuropathologically diagnosed PD subjects lacking Alzheimer's disease (AD) neuropathology. In the present study, we assessed these biomarkers as well as p-tau(181), Aβ42, and S100B by ELISA in PD (n = 43) and NC (n = 49) cases. The p-tau(181)/Aβ42 ratio and ApoA-1 showed statistically significant differences between groups. Multiple regression analysis demonstrated that p-tau(181)/Aβ42 had a significant odds ratio: OR = 1.42 (95% confidence interval [CI], 1.12-1.84), P = 0.006. Among the molecules investigated, intriguing correlations were observed that require further investigation. Our results suggest coexistent AD CSF biomarkers within the PD group notwithstanding that it was selected to minimize AD neuropathological lesions.

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