Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer | Zendy

Soley Bayraktar | Zendy; Hongming Qiu | Zendy; Diane Liu | Zendy; Yu Shen | Zendy; Angelica M. GutierrezBarrera | Zendy; Banu K. Arun | Zendy; Ayşegül A. Şahin | Zendy

Open Access

Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer

Author(s) -

Soley Bayraktar,

Hongming Qiu,

Diane Liu,

Yu Shen,

Angelica M. GutierrezBarrera,

Banu K. Arun,

Ayşegül A. Şahin

Publication year - 2015

Publication title -

biomarkers in cancer

Language(s) - English

Resource type - Journals

ISSN - 1179-299X

DOI - 10.4137/bic.s29716

Subject(s) - medicine , breast cancer , parenchyma , brca mutation , stromal cell , pathology , oncology , cancer

Several studies have evaluated histologic features of non-neoplastic breast parenchyma in patients with BRCA1/2 mutations, but the results are conflicting. The limited data suggest a much higher prevalence of high-risk precursor lesions in BRCA carriers. Therefore, we designed this study to compare the clinicopathological characteristics of peritumoral benign breast tissue in patients with and without deleterious BRCA mutations.

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