Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug | Zendy

Kei Shimoda | Zendy; Manabu Hamada | Zendy; Hiroshi Yokoi | Zendy; Hiroki Hamada | Zendy

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Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug

Author(s) -

Kei Shimoda,

Manabu Hamada,

Hiroshi Yokoi,

Hiroki Hamada

Publication year - 2012

Publication title -

biochemistry insights

Language(s) - English

Resource type - Journals

ISSN - 1178-6264

DOI - 10.4137/bci.s9961

Subject(s) - conjugate , monosaccharide , chemistry , enzyme , cytotoxicity , prodrug , stereochemistry , biochemistry , in vitro , mathematical analysis , mathematics

Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester showed no cytotoxicity and induced no apoptosis.

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