Chemo-Enzymatic Synthesis of Glycolyl-Ester-Linked Taxol-Monosaccharide Conjugate and Its Drug Delivery System Using Hepatitis B Virus Envelope L Bio-Nanocapsules | Zendy

Kei Shimoda | Zendy; Manabu Hamada | Zendy; Masaharu Seno | Zendy; Tadakatsu Mandai | Zendy; Hiroki Hamada | Zendy

Open Access

Chemo-Enzymatic Synthesis of Glycolyl-Ester-Linked Taxol-Monosaccharide Conjugate and Its Drug Delivery System Using Hepatitis B Virus Envelope L Bio-Nanocapsules

Author(s) -

Kei Shimoda,

Manabu Hamada,

Masaharu Seno,

Tadakatsu Mandai,

Hiroki Hamada

Publication year - 2012

Publication title -

biochemistry insights

Language(s) - English

Resource type - Journals

ISSN - 1178-6264

DOI - 10.4137/bci.s9824

Subject(s) - conjugate , nanocapsules , chemistry , hepatitis b virus , enzyme , monosaccharide , hepatocellular carcinoma , glucoside , biocatalysis , drug delivery , combinatorial chemistry , biochemistry , nuclear chemistry , virus , organic chemistry , virology , nanotechnology , materials science , nanoparticle , catalysis , biology , medicine , cancer research , mathematical analysis , mathematics , alternative medicine , pathology , ionic liquid

Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2″-O-α-D-glucoside, was achieved by using α-glucosidase as a biocatalyst. The water-solubility of 7-glycolyltaxol 2″-O-α-D-glucoside (21 μM) was 53 fold higher than that of taxol. The hepatitis B virus envelope L particles (bio-nanocapsules) are effective for delivering 7-glycolyltaxol 2″-O-α-D-glucoside to human hepatocellular carcinoma NuE cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research