Enzymatic Synthesis and Anti-Allergic Activities of Curcumin Oligosaccharides | Zendy

Kei Shimoda | Zendy; Hiroki Hamada | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Enzymatic Synthesis and Anti-Allergic Activities of Curcumin Oligosaccharides

Author(s) -

Kei Shimoda,

Hiroki Hamada

Publication year - 2010

Publication title -

biochemistry insights

Language(s) - English

Resource type - Journals

ISSN - 1178-6264

DOI - 10.4137/bci.s2768

Subject(s) - curcumin , chemistry , histamine , glycosylation , enzyme , glycoside , biochemistry , cyclodextrin , pharmacology , stereochemistry , biology

Curcumin 4‘- O -glucooligosaccharides were synthesized by a two step-enzymatic method using almond β-glucosidase and cyclodextrin glucanotransferase (CGTase). Curcumin was glucosylated to curcumin 4‘- O -β-D-glucopyranoside by almond β-glucosidase in 19% yield. Curcumin 4‘- O -β-D-glucopyranoside was converted into curcumin 4‘- O -β-glucooligosaccharides, i.e. 4‘- O -β-maltoside (51%) and 4‘- O -β-maltotrioside (25%), by further CGTase-catalyzed glycosylation. Curcumin 4‘- O -β-glycosides showed suppressive action on IgE antibody formation and inhibitory effects on histamine release from rat peritoneal mast cells

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research