Insulin-Like Growth Factor 1 Gene Polymorphism and Breast Cancer Risk among Arab Omani Women: A Case-Control Study | Zendy

Kawthar Al-Ajmi | Zendy; Shyam S Ganguly | Zendy; Adil Al-Ajmi | Zendy; Zahid Al Mandhari | Zendy; Mansour AlMoundhri | Zendy

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Insulin-Like Growth Factor 1 Gene Polymorphism and Breast Cancer Risk among Arab Omani Women: A Case-Control Study

Author(s) -

Kawthar Al-Ajmi,

Shyam S Ganguly,

Adil Al-Ajmi,

Zahid Al Mandhari,

Mansour AlMoundhri

Publication year - 2012

Publication title -

breast cancer basic and clinical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.741

H-Index - 23

ISSN - 1178-2234

DOI - 10.4137/bcbcr.s9784

Subject(s) - allele , breast cancer , genotyping , genotype , biology , medicine , case control study , insulin like growth factor , oncology , cancer , gene , genetics , endocrinology , growth factor , receptor

Breast cancer is the most common cancer worldwide with significant global burden. Insulin-like growth factor 1 (IGF1) is an important regulator of cellular growth, differentiation, and apoptosis and mitogenic and antiapoptotic activities. Some studies suggested an association between cytosine adenine (CA) repeats gene polymorphisms of IGF1 and the risk of developing breast cancer while other studies did not find such an association. This study aims investigate the role of IGF1 (CA) repeats gene polymorphisms in the risk of developing breast cancer among Omani women.

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