Delivery of MicroRNA-10b with Polylysine Nanoparticles for Inhibition of Breast Cancer Cell Wound Healing | Zendy

Hongjun Jin | Zendy; Yuehua Yu | Zendy; William Chrisler | Zendy; Yijia Xiong | Zendy; Dehong Hu | Zendy; Chenghong Lei | Zendy

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Delivery of MicroRNA-10b with Polylysine Nanoparticles for Inhibition of Breast Cancer Cell Wound Healing

Author(s) -

Hongjun Jin,

Yuehua Yu,

William Chrisler,

Yijia Xiong,

Dehong Hu,

Chenghong Lei

Publication year - 2011

Publication title -

breast cancer basic and clinical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.741

H-Index - 23

ISSN - 1178-2234

DOI - 10.4137/bcbcr.s8513

Subject(s) - rna , microrna , polylysine , cancer research , breast cancer , cell culture , chemistry , metastatic breast cancer , wound healing , cancer , microbiology and biotechnology , biology , medicine , immunology , biochemistry , gene , genetics

Recent studies revealed that micro RNA-10b (mir-10b) is highly expressed in metastatic breast cancer cells and positively regulates breast cancer cell migration and invasion through inhibition of HOXD10 target synthesis. In this study we designed anti-mir-10b molecules and combined them with poly L-lysine (PLL) to test the delivery effectiveness. An RNA molecule sequence exactly matching the mature mir-10b minor antisense showed strong inhibition when mixed with PLL in a wound-healing assay with human breast cell line MDA-MB-231. The resulting PLL-RNA nanoparticles delivered the anti-microRNA molecules into cytoplasm of breast cancer cells in a concentration-dependent manner that displayed sustainable effectiveness.

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