Computational andin vitroInvestigation of miRNA-Gene Regulations in Retinoblastoma Pathogenesis: miRNA Mimics Strategy | Zendy

Nalini Venkatesan | Zendy; Perinkulam Ravi Deepa | Zendy; Vikas Khetan | Zendy; Subramanian Krishnakumar | Zendy

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Computational andin vitroInvestigation of miRNA-Gene Regulations in Retinoblastoma Pathogenesis: miRNA Mimics Strategy

Author(s) -

Nalini Venkatesan,

Perinkulam Ravi Deepa,

Vikas Khetan,

Subramanian Krishnakumar

Publication year - 2015

Publication title -

bioinformatics and biology insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 23

ISSN - 1177-9322

DOI - 10.4137/bbi.s21742

Subject(s) - microrna , retinoblastoma , mirbase , biology , in silico , gene , cancer research , computational biology , cell cycle , hmga2 , genetics , bioinformatics , microbiology and biotechnology

Retinoblastoma (RB), a primary pediatric intraocular tumor, arises from primitive retinal layers. Several novel molecular strategies are being developed for the clinical management of RB. miRNAs are known to regulate cancer-relevant biological processes. Here, the role of selected miRNAs, namely, miR-532-5p and miR-486-3p, has been analyzed for potential therapeutic targeting in RB.

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