Article Commentary: Promise and Reality in the Expanding Field of Network Interaction Analysis: Metabolic Networks | Zendy

Susanna Bazzani | Zendy

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Article Commentary: Promise and Reality in the Expanding Field of Network Interaction Analysis: Metabolic Networks

Author(s) -

Susanna Bazzani

Publication year - 2014

Publication title -

bioinformatics and biology insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 23

ISSN - 1177-9322

DOI - 10.4137/bbi.s12466

Subject(s) - metabolic network , systems biology , cellular metabolism , computer science , biological network , field (mathematics) , computational biology , data science , process (computing) , metabolic engineering , management science , bioinformatics , biology , metabolism , engineering , biochemistry , mathematics , pure mathematics , enzyme , operating system

In the last few decades, metabolic networks revealed their capabilities as powerful tools to analyze the cellular metabolism. Many research fields (eg, metabolic engineering, diagnostic medicine, pharmacology, biochemistry, biology and physiology) improved the understanding of the cell combining experimental assays and metabolic network-based computations. This process led to the rise of the "systems biology" approach, where the theory meets experiments and where two complementary perspectives cooperate in the study of biological phenomena. Here, the reconstruction of metabolic networks is presented, along with established and new algorithms to improve the description of cellular metabolism. Then, advantages and limitations of modeling algorithms and network reconstruction are discussed.

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