Association between a Prognostic Gene Signature and Functional Gene Sets | Zendy

Manuela Hummel | Zendy; Klaus H. Metzeler | Zendy; Christian Buske | Zendy; Stefan K. Bohlander | Zendy; Ulrich Mansmann | Zendy

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Association between a Prognostic Gene Signature and Functional Gene Sets

Author(s) -

Manuela Hummel,

Klaus H. Metzeler,

Christian Buske,

Stefan K. Bohlander,

Ulrich Mansmann

Publication year - 2008

Publication title -

bioinformatics and biology insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 23

ISSN - 1177-9322

DOI - 10.4137/bbi.s1018

Subject(s) - gene signature , computational biology , gene , context (archaeology) , gene regulatory network , signature (topology) , set (abstract data type) , gene expression profiling , gene expression , biology , bioinformatics , genetics , computer science , mathematics , paleontology , geometry , programming language

The development of expression-based gene signatures for predicting prognosis or class membership is a popular and challenging task. Besides their stringent validation, signatures need a functional interpretation and must be placed in a biological context. Popular tools such as Gene Set Enrichment have drawbacks because they are restricted to annotated genes and are unable to capture the information hidden in the signature's non-annotated genes.

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