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Background: Drug-induced liver injury is of great interest especially drugs that broadly used like acetaminophen. Objective: To assess new model of acetaminophen-induced acute hepatic injury and Vitamin D3 effectiveness. Materials and Methods: Eighteen male rabbits allocated into three groups six rabbits for each. Group 1 receives acetaminophen to induce acute hepatic injury and Group 2 receive single injection of Vitamin D3 before induction of hepatic injury, and group 3 was control. After 24 h from three-spaced injection of acetaminophen sample of blood taken to measure serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, and albumin. Results: Successful model of acetaminophen-induced hepatic injury achieved by significant elevation (P ≤ 0.05) of ALT and AST of Group 1 and 2 compared with control. No significance variation observed (P ≥ 0.05) between treatment Group 1 and 2 in liver function enzymes level. Conclusion: A new easy model of acetaminophen-induced acute hepatic injury effectively obtained. Although no statistical signifi cant Vitamin D3 lower the levels of ALT and AST.

New animal model of induced acute hepatic injury by acetaminophen and Vitamin D3 protective effect