Dihydroartemisinin induces apoptosis in human bladder cancer cell lines through reactive oxygen species, mitochondrial membrane potential, and cytochrome C pathway | Zendy

Mahmoud Aghaei | Zendy; Farhad Poupel | Zendy; Ahmad Movahedian | Zendy; SeyyedMehdi Jafari | Zendy; MohammadKeyvanloo Shahrestanaki | Zendy

Open Access

Dihydroartemisinin induces apoptosis in human bladder cancer cell lines through reactive oxygen species, mitochondrial membrane potential, and cytochrome C pathway

Author(s) -

Mahmoud Aghaei,

Farhad Poupel,

Ahmad Movahedian,

SeyyedMehdi Jafari,

MohammadKeyvanloo Shahrestanaki

Publication year - 2017

Publication title -

international journal of preventive medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.539

H-Index - 39

eISSN - 2008-8213

pISSN - 2008-7802

DOI - 10.4103/ijpvm.ijpvm_258_17

Subject(s) - reactive oxygen species , apoptosis , dihydroartemisinin , cytochrome c , medicine , mitochondrion , microbiology and biotechnology , inner mitochondrial membrane , membrane potential , cytochrome , cancer research , biochemistry , biology , pathology , artemisinin , malaria , plasmodium falciparum , enzyme

These findings demonstrated that DHA induces apoptosis through mitochondrial signaling pathway. These suggest that DHA may be a potential agent for induction of apoptosis in human bladder cancer cells.

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