A novel protein tyrosine phosphatase 1B inhibitor from Tinospora sinensis | Zendy

Prasoon Gupta | Zendy; PraveenK Gupta | Zendy; Upasana Sharma | Zendy; Rakesh Maurya | Zendy

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A novel protein tyrosine phosphatase 1B inhibitor from Tinospora sinensis

Author(s) -

Prasoon Gupta,

PraveenK Gupta,

Upasana Sharma,

Rakesh Maurya

Publication year - 2012

Publication title -

chronicles of young scientists

Language(s) - English

Resource type - Journals

eISSN - 2229-5186

pISSN - 0975-9212

DOI - 10.4103/2229-5186.99569

Subject(s) - protein tyrosine phosphatase , phosphatase , chemistry , biochemistry , dusp6 , protein phosphatase 2 , tyrosine , enzyme

Bioassay-directed fractionation led to the identification of a new compound, 4-hydroxy-heptadec-6-enoic acid ethyl ester (1) together with three known compounds (2-4) from Tinospora sinensis. The structure of 1 was determined by analysis of spectroscopic data. The isolated compounds were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compounds 1 and 2 displayed significant inhibitory activity with IC 50 values 61.1 and 74.2 μM, respectivel

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