Regarding “A Process‐Based Review of Mouse Models of Pulmonary Hypertension”

We wish to respond to the review article by Mita Das et al. entitled “A process-based review of mouse models of pulmonary hypertension” (Pulmonary Circulation OctoberDecember 2012:2[4]). Genetically modified mouse models have provided curious data for researchers in cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging, and Parkinson’s disease; but how cost-effective or translational is this mouse research? Just one gene knockout kit will set you back US $ 38,000.[1] Crowley[2] and Contopoulos-Ioannidis et al.[3] have shown that successful translation to humans for this kind of basic research is exceedingly rare.[4]