Open AccessRegarding “A Process‐Based Review of Mouse Models of Pulmonary Hypertension”
Author(s) -
Menache Andre,
Keogh Anne
Publication year - 2013
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.4103/2045-8932.114782
Subject(s) - medicine , context (archaeology) , pulmonary hypertension , disease , translational research , bioinformatics , computational biology , pathology , biology , paleontology
We wish to respond to the review article by Mita Das et al. entitled “A process-based review of mouse models of pulmonary hypertension” (Pulmonary Circulation OctoberDecember 2012:2[4]). Genetically modified mouse models have provided curious data for researchers in cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging, and Parkinson’s disease; but how cost-effective or translational is this mouse research? Just one gene knockout kit will set you back US $ 38,000.[1] Crowley[2] and Contopoulos-Ioannidis et al.[3] have shown that successful translation to humans for this kind of basic research is exceedingly rare.[4]