z-logo
open-access-imgOpen Access
On the Origin of Microparticles: From “Platelet Dust” to Mediators of Intercellular Communication
Author(s) -
Hargett Leslie A.,
Bauer Natalie N.
Publication year - 2013
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.4103/2045-8932.114760
Subject(s) - coagulation , microparticle , platelet , medicine , vesicle , microbiology and biotechnology , immunology , biology , biochemistry , membrane , astrobiology
Microparticles are submicron vesicles shed from a variety of cells. Peter Wolf first identified microparticles in the midst of ongoing blood coagulation research in 1967 as a product of platelets. He termed them platelet dust. Although initially thought to be useless cellular trash, decades of research focused on the tiny vesicles have defined their roles as participators in coagulation, cellular signaling, vascular injury, and homeostasis. The purpose of this review is to highlight the science leading up to the discovery of microparticles, feature discoveries made by key contributors to the field of microparticle research, and discuss their positive and negative impact on the pulmonary circulation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here