Open AccessNitric Oxide Deficiency in Pulmonary Hypertension: Pathobiology and Implications for Therapy
Author(s) -
Tonelli Adriano R.,
Haserodt Sarah,
Aytekin Metin,
Dweik Raed A.
Publication year - 2013
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.4103/2045-8932.109911
Subject(s) - medicine , pulmonary hypertension , nitric oxide , disease , lung disease , bioinformatics , lung , intensive care medicine , pathology , biology
Nitric oxide (NO) is a diffusible gas with diverse roles in human physiology and disease. Significant progress in the understanding of its biological effects has taken place in recent years. This has led to a better understanding of the pathobiology of pulmonary hypertension (PH) and the development of new therapies. This article provides an overview of the NO physiology and its role in the pathobiology of lung diseases, particularly PH. We also discuss current and emerging specific treatments that target NO signaling pathways in PH.