Negative response of phytoestrogens of pomegranate flower extract against cisplatin-induced nephrotoxicity in female rats | Zendy

Amr Ahmed El–Arabey | Zendy

Open Access

Negative response of phytoestrogens of pomegranate flower extract against cisplatin-induced nephrotoxicity in female rats

Author(s) -

Amr Ahmed El–Arabey

Publication year - 2016

Publication title -

international journal of preventive medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.539

H-Index - 39

eISSN - 2008-8213

pISSN - 2008-7802

DOI - 10.4103/2008-7802.184751

Subject(s) - medicine , phytoestrogens , nephrotoxicity , cisplatin , traditional medicine , pharmacology , kidney , chemotherapy , estrogen

male rats which responsible for CP uptake.[5] However, estrogen abolishes protective effects of erythropoietin against CP‐induced nephrotoxicity in ovariectomized rats and increases oxidative stress in the kidney.[6,7] It also abolishes protective effects of Vitamin E against CP‐induced nephrotoxicity.[8] Finally, I support my first conclusion as PEF contains phytoestrogens, which have estrogenic activity which accountable for increase CP potency and kidney damage to a higher extent. Hence, PEF does not prevent CP‐induced nephrotoxicity in female rats.

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