Comment on: Prevention of renal damage by treating hyperuricemia

potential therapeutic approach to control of blood pressure in patients on hemodialysis.[12‐14] Interestingly it was shown that treatment of hyperuricemia increases 1,25(OH) 2D levels, proposing that hyperuricemia may have a suppressive effect on 1‐α hydroxylase activity.[15] It is possible that high plasma uric acid levels reduce 1,25(OH) 2D levels by suppressing 1‐α hydroxylase and, while low 1,25(OH) 2D levels can stimulate parathyroid hormone (PTH) that high uric acid levels should be associated with elevated PTH levels too.[2,15‐21] In accord with this hypothesis, Chen et al., in in vivo study on Sprague Dawley rats, found uric acid suppresses 1‐α hydroxylase in vitro and in vivo.[15] In fact, a reduction in 1,25(OH) 2D secondary to reduced 1‐α hydroxylase enzyme activity contributes to the development of secondary hyperparathyroidism in patients with chronic kidney disease.[2,15‐21] Indeed, the direct association of hyperuricemia and Vitamin D metabolism has two consequences. First, it is well understand that hyperuricemia by itself is an independent risk factor for kidney damage in various nephropathies like IgA nephropathy or diabetic kidney disease.[2,16‐24] Many studies, support the hypothesis that elevated uric acid levels might have an injurious effect, resulting to inflammation, endothelial dysfunction, and vascular disease.[2,9,11,15‐17] Second, except the deleterious effect of hyperuricemia on hypertension and aggravation of some type of nephropathies, its harmful effect of Vitamin D production is of significant importance.[15‐23] Many studies had shown, support Vitamin D as a negative regulator of the circulating and local tissue renin‐angiotensin system (RAS), since RAS has a critical implication in the physiology of sodium and volume homeostasis, hence, excess activity of RAS is associated with high blood pressure, kidney disease, How to cite this article: Nasri H, Ardalan M, Rafieian-Kopaei M. Comment on: Prevention of renal damage by treating hyperuricemia. Int J Prev Med 2015;6:10.