Simultaneous determination of related substances of telmisartan and hydrochlorothiazide in tablet dosage form by using reversed phase high performance liquid chromatographic method | Zendy

Sutirtho Mukhopadhyay | Zendy; Kiran D. Kadam | Zendy; Laxman Sawant | Zendy; Dhanashree Nachane | Zendy; Nancy Pandita | Zendy

Open Access

Simultaneous determination of related substances of telmisartan and hydrochlorothiazide in tablet dosage form by using reversed phase high performance liquid chromatographic method

Author(s) -

Sutirtho Mukhopadhyay,

Kiran D. Kadam,

Laxman Sawant,

Dhanashree Nachane,

Nancy Pandita

Publication year - 2011

Publication title -

journal of pharmacy and bioallied sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 36

eISSN - 0976-4879

pISSN - 0975-7406

DOI - 10.4103/0975-7406.84441

Subject(s) - telmisartan , hydrochlorothiazide , chromatography , chemistry , dosage form , losartan potassium , high performance liquid chromatography , anhydrous , solvent , potassium , acetonitrile , angiotensin ii , medicine , losartan , biochemistry , receptor , organic chemistry , blood pressure

Telmisartan is a potent, long-lasting, nonpeptide antagonist of the angiotensin II type-1 (AT(1)) receptor that is indicated for the treatment of essential hypertension. Hydrochlorothiazide is a widely prescribed diuretic and it is indicated for the treatment of edema, control of essential hypertension and management of diabetes insipidus. In the current article a new, accurate, sensitive, precise, rapid, reversed phase high performance liquid chromatography (RP-HPLC) method was developed for determination of related substances of Telmisartan and Hydrochlorthiazide in tablet dosage form.

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