Open AccessDissofilm: A Novel Approach for Delivery of Phenobarbital; Design and Characterization
Author(s) -
Shiva Kumar Yellanki,
Sneha Jagtap,
Rajashree Masareddy
Publication year - 2011
Publication title -
journal of young pharmacists
Language(s) - English
Resource type - Journals
eISSN - 0975-1505
pISSN - 0975-1483
DOI - 10.4103/0975-1483.83756
Subject(s) - dissolution , plasticizer , phenobarbital , in vivo , solvent , materials science , population , drug delivery , solubility , kinetics , chemistry , pharmacology , chemical engineering , nuclear chemistry , chromatography , nanotechnology , organic chemistry , medicine , composite material , microbiology and biotechnology , physics , engineering , environmental health , biology , quantum mechanics
An attempt to develop and evaluate mouth-dissolving film of phenobarbital for quick effect in treatment of epilepsy occurring in pediatric population has been made in the present study. Suitable film formers and plasticizers are selected based on optimization studies. Effect of superdisintegrants in formulation of mouth dissolving films at different concentrations has been investigated. Films were prepared by solvent casting method. The prepared films were evaluated for physicochemical parameters, in vitro disintegration and dissolution time, in vitro release rate study, stability study, and in vivo animal safety study. The best formulation was found to be F3 showing 96.57% drug release in 14 min, following first-order kinetics. X-Ray diffraction studies show change in crystalline nature of drug in formulation. In vivo studies in hamster reports effective and safe use of formulation in animals.