Immunogenicity of OmpA and OmpB antigens from Rickettsia rickettsii on mononuclear cells from Rickettsia positive Mexican patients | Zendy

Karla DzulRosado | Zendy; Javier Balam-Romero | Zendy; Guillermo ValenciaPacheco | Zendy; César LugoCaballero | Zendy; Juan Arias-León | Zendy; Gaspar Peniche-Lara | Zendy; Jorge Zavala-Castro | Zendy

Open Access

Immunogenicity of OmpA and OmpB antigens from Rickettsia rickettsii on mononuclear cells from Rickettsia positive Mexican patients

Author(s) -

Karla DzulRosado,

Javier Balam-Romero,

Guillermo ValenciaPacheco,

César LugoCaballero,

Juan Arias-León,

Gaspar Peniche-Lara,

Jorge Zavala-Castro

Publication year - 2017

Publication title -

journal of vector borne diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.581

H-Index - 41

ISSN - 0972-9062

DOI - 10.4103/0972-9062.225836

Subject(s) - immunogenicity , plasmid , antigen , rickettsia rickettsii , biology , immune system , peripheral blood mononuclear cell , virology , microbiology and biotechnology , epitope , transfection , immunology , in vitro , cell culture , spotted fever , dna , rickettsia , biochemistry , genetics , virus

The nature of the rickettsial antigens and the immune response generated by them, have been the subject of exhaustive research so that a suitable vaccine can be developed. Till date evaluations of Rickettsia rickettsii antigens that induce both humoral and cellular responses in animal models have only shown partial protection and short-term immunological memory. This study was aimed to evaluate the immune response induced by DNA plasmids generated from the OmpA and OmpB genes of R. rickettsii in peripheral blood mononuclear cells of rickettsial (sensitized) patients compared to healthy subjects.

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