Proliferative and morphologic characterization of buccal mucosal fibroblasts in areca nut chewers: A cell culture study | Zendy

Deepu George Mathew | Zendy; Kannan Ranganathan | Zendy; KSkariah Skariah | Zendy

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Proliferative and morphologic characterization of buccal mucosal fibroblasts in areca nut chewers: A cell culture study

Author(s) -

Deepu George Mathew,

Kannan Ranganathan,

KSkariah Skariah

Publication year - 2011

Publication title -

indian journal of dental research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 43

eISSN - 1998-3603

pISSN - 0970-9290

DOI - 10.4103/0970-9290.94693

Subject(s) - oral submucous fibrosis , areca , buccal administration , fibroblast , buccal mucosa , collagenase , pathology , mitosis , biology , nut , cell culture , medicine , dentistry , microbiology and biotechnology , oral cavity , genetics , biochemistry , enzyme , structural engineering , engineering

Objective: To isolate, culture and characterize fibroblasts from the buccal mucosa of areca nut chewers with and without oral submucous fibrosis (OSF). Materials and Methods: Primary fibroblast cultures were established by the collagenase disaggregation technique and the phenotypic and growth characteristics were studied. Results: Cells cultured from OSF showed a statistically significant increase in both the post-mitotic fibroblast subpopulation and the population doubling time when compared with controls.Conclusion: There was a significant increase in the pro-fibrotic, post-mitotic subpopulation of fibroblasts in areca nut chewers with OSF

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