Open AccessReport of rpoB mutation in clinically suspected cases of drug resistant leprosy: A study from Eastern India
Author(s) -
Basudev Bhattacharya,
AbuHena Hasanoor Reja,
Nibir Biswas,
Supratik Biswas,
Mallika Lavania,
VedithiSundeep Chaitanya,
Surajita Banerjee,
PrasantaSinha Maha Patra,
UmeshDutta Gupta,
PradipKumar Patra,
Utpal Sengupta
Publication year - 2015
Publication title -
indian journal of dermatology venereology and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/0378-6323.152185
Subject(s) - rpob , mycobacterium leprae , point mutation , biology , leprosy , drug resistance , gene , genetics , polymerase chain reaction , missense mutation , dna sequencing , mutation , immunology , 16s ribosomal rna
The current strategy for leprosy control depends mainly on early case detection and providing the recommended multidrug therapy (MDT) dosage. Understanding the molecular mechanisms of drug resistance to each of these drugs is essential in providing effective treatment and preventing the spread of resistant strains in the community. The progress of molecular biology research provides a very efficient opportunity for the diagnosis of drug resistance by in vitro method.
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