Open Access-174G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease
Author(s) -
Lakhdar Ghazouani,
Nesrine Abboud,
S. Ben Khalifa,
Faouzi Added,
A Khalfallah,
Brahim Nsiri,
Mounira Mediouni,
Touhami Mahjoub
Publication year - 2011
Publication title -
annals of saudi medicine/annals of saudi medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.373
H-Index - 44
eISSN - 0975-4466
pISSN - 0256-4947
DOI - 10.4103/0256-4947.75777
Subject(s) - pharmacy , medicine , biology , family medicine
A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians.