Antibacterial activity of the venom of Heterometrus xanthopus | Zendy

Nauman Khalid | Zendy; Umair Ahmed | Zendy; Malik Mujaddad-ur-Rehman | Zendy; SardarAtiq Fawad | Zendy; Anees Fatima | Zendy

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Antibacterial activity of the venom of Heterometrus xanthopus

Author(s) -

Nauman Khalid,

Umair Ahmed,

Malik Mujaddad-ur-Rehman,

SardarAtiq Fawad,

Anees Fatima

Publication year - 2012

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.99332

Subject(s) - venom , bacillus subtilis , enterococcus faecalis , microbiology and biotechnology , serial dilution , pseudomonas aeruginosa , biology , scorpion , enterococcus , chemistry , antibacterial activity , salmonella , bacteria , staphylococcus aureus , antibiotics , biochemistry , medicine , genetics , alternative medicine , pathology

Heterometrus xanthopus (Scorpion) is one of the most venomous and ancient arthropods. Its venom contains anti-microbial peptides like hadrurin, scorpine, Pandinin 1, and Pandinin 2 that are able to effectively kill multidrug-resistant pathogens. The present study was conducted to evaluate the anti-bacterial activity of H. xanthopus venom. Six Gram-positive and Gram-negative bacterial strains were tested against 1/100, 1/10, and 1/1 fractions of distilled water diluted and crude venom. 1/100 and 1/10 dilutions were not successful in any of the six bacterial strains studied while the 1/1 dilution was effective on Bacillus subtilis ATCC 6633, Salmonella typhimurium ATCC 14028, and Pseudomonas aeruginosa ATCC 27853 with highest zone of inhibition were obtained on B. subtilis. Crude venom was effective against Enterococcus faecalis ATCC 14506, B. subtilis, S. typhimurium, and P. aeruginosa. The most effective results were observed on B. subtilis.

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