Animal models and biomarkers of neuropathy in diabetic rodents | Zendy

RS Somani | Zendy; Abusufyan Shaikh | Zendy

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Animal models and biomarkers of neuropathy in diabetic rodents

Author(s) -

RS Somani,

Abusufyan Shaikh

Publication year - 2010

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.66833

Subject(s) - diabetes mellitus , medicine , diabetic neuropathy , animal model , type 2 diabetes , pathological , etiology , bioinformatics , animal studies , endocrinology , biology

Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal models and biomarkers of DN have been extensively used in neuropathic research. The most useful model of DN should exhibit the key feature present in human pathology. Diabetic rodents show behavioral, functional, structural and molecular biomarkers and they are widely used as models to investigate the etiology of DN as well as to screen the efficacy of the potential therapeutic interventions. We have reviewed the different animal models and biomarkers of neuropathy in diabetic rodents of either type 1 or type 2 diabetes.

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