Cloned Theileria parva produces lesser infections in ticks compared to uncloned T. parva despite similar infections in cattle : research communication | Zendy

A.R. Walker | Zendy; Frank Katzer | Zendy; Daniel Ngugi | Zendy; Declan J. McKeever | Zendy

Open Access

Cloned Theileria parva produces lesser infections in ticks compared to uncloned T. parva despite similar infections in cattle : research communication

Author(s) -

A.R. Walker,

Frank Katzer,

Daniel Ngugi,

Declan J. McKeever

Publication year - 2006

Publication title -

onderstepoort journal of veterinary research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.563

H-Index - 35

eISSN - 2219-0635

pISSN - 0030-2465

DOI - 10.4102/ojvr.v73i2.163

Subject(s) - theileria parva , biology , east coast fever , tick , nymph , veterinary medicine , virology , vector (molecular biology) , zoology , parasite hosting , genetics , gene , medicine , world wide web , computer science , recombinant dna

Experimental transmissions of cloned Theileria parva in cattle with Rhipicephalus appendiculatus ticks were compared to transmissions with uncloned T. parva during studies on the potential for genetic recombination during syngamy of Theileria to produce antigenic diversity for evasion of bovine immunity. Prevalence and abundance of T. parva infection in adult ticks, which resulted from the feeding of nymphs on the calves, were significantly higher in the uncloned compared to the cloned T. parva. Development of sporoblasts of T. parva in the ticks to produce infective sporozoites was similar. There was no statistically significant difference in the clinical course of infection in cattle between cloned and uncloned T. parva. It was concluded that cloned T. parva has characteristics that reduce its viability during the tick stages of its life cycle.

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