Thyroid carcino-sarcoma in a dog | Zendy

Antônio Giuliano | Zendy; Jessica Grant | Zendy; Jérôme Benoît | Zendy

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Thyroid carcino-sarcoma in a dog

Author(s) -

Antônio Giuliano,

Jessica Grant,

Jérôme Benoît

Publication year - 2013

Publication title -

journal of the south african veterinary association

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.535

H-Index - 31

eISSN - 2224-9435

pISSN - 1019-9128

DOI - 10.4102/jsava.v84i1.120

Subject(s) - medicine , sarcoma , carboplatin , chemotherapy , radiation therapy , cytokeratin , metastasis , thyroid , histopathology , oncology , cyclophosphamide , pathology , cisplatin , immunohistochemistry , cancer

An adult male greyhound was diagnosed with a thyroid carcino-sarcoma by means of histopathology and positive immuno-histochemistry staining for cytokeratin and vimentin. Surgery and radiotherapy of the area were successful in local tumour control. Adjuvant chemotherapy was recommended to treat and prevent further metastasis. The use of carboplatin, metronomic cyclophosphamide chemotherapy and toceranib failed to control the progression of distant metastasis. The survival time was seven months from the time of diagnosis. This is the eighth case of carcino-sarcoma of the thyroid documented in veterinary medicine and the first one treated with a multimodal approach based on surgery, radiotherapy and chemotherapy. As documented in human medicine, chemotherapy appeared to be ineffective to prevent or delay the progression of the metastatic disease in this case.

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