Some clinical effects of midazolam premedication in propofol-induced and isoflurane-maintained anaesthesia in dogs during ovariohysterectomy | Zendy

G.F. Stegmann | Zendy; Lynette Bester | Zendy

Open Access

Some clinical effects of midazolam premedication in propofol-induced and isoflurane-maintained anaesthesia in dogs during ovariohysterectomy

Author(s) -

G.F. Stegmann,

Lynette Bester

Publication year - 2001

Publication title -

journal of the south african veterinary association

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.535

H-Index - 31

eISSN - 2224-9435

pISSN - 1019-9128

DOI - 10.4102/jsava.v72i4.655

Subject(s) - premedication , propofol , midazolam , anesthesia , isoflurane , medicine , placebo , reflex , general anaesthesia , sedation , alternative medicine , pathology

In a randomised, placebo-controlled clinical trial, anaesthesia was induced with propofol (4 mg/kg) after intravenous premedication with or without midazolam (0.1 mg/kg), in a group of 8 dogs scheduled for ovariohysterectomy. Midazolam administration induced acute behavioural changes, and increased reflex suppression after propofol induction. Compared to the control group, the dose required to obtain loss of the pedal reflex was significantly reduced by 37%, and the end-tidal isoflurane concentration during maintenance, reduced by 23%.

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