Association Study of Trauma Load andSLC6A4Promoter Polymorphism in Posttraumatic Stress Disorder
Author(s) -
IrisTatjana Kolassa,
Verena Ertl,
Cindy Eckart,
Franka Glöckner,
Stephan Kolassa,
Andreas Papassotiropoulos,
Dominique J.F. de Quervain,
Thomas Elbert
Publication year - 2010
Publication title -
the journal of clinical psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 207
eISSN - 1534-8628
pISSN - 0160-6689
DOI - 10.4088/jcp.08m04787blu
Subject(s) - serotonin transporter , stressor , traumatic stress , genotype , 5 httlpr , clinical psychology , psychiatry , psychology , medicine , genetics , gene , biology
As exposure to different types of traumatic stressors increases, the occurrence of posttraumatic stress disorder (PTSD) increases. However, because some people exhibit either surprising resilience or high vulnerability, further influencing factors have been conjectured, such as gene-environment interactions. The SLC6A4 gene, which encodes serotonin transporter, has been identified as predisposing toward differential emotional processing between genotypes of its promoter polymorphism.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom