Association of Adverse Childhood Environment and5-HTTLPRGenotype With Late-Life Depression | Zendy

Karen Ritchie | Zendy; Isabelle Jaussent | Zendy; Robert Stewart | Zendy; AnneMarie Dupuy | Zendy; Philippe Courtet | Zendy; MarieLaure Ancelin | Zendy; Alain Malafosse | Zendy

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Association of Adverse Childhood Environment and5-HTTLPRGenotype With Late-Life Depression

Author(s) -

Karen Ritchie,

Isabelle Jaussent,

Robert Stewart,

AnneMarie Dupuy,

Philippe Courtet,

MarieLaure Ancelin,

Alain Malafosse

Publication year - 2009

Publication title -

the journal of clinical psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 207

eISSN - 1534-8628

pISSN - 0160-6689

DOI - 10.4088/jcp.08m04510

Subject(s) - depression (economics) , psychology , psychiatry , physical abuse , 5 httlpr , population , major depressive disorder , clinical psychology , child abuse , medicine , serotonin transporter , poison control , injury prevention , cognition , receptor , environmental health , serotonin , economics , macroeconomics

Neurobiological and clinical studies suggest that childhood maltreatment may result in functional and structural nervous system changes that predispose the individual to depression. This vulnerability appears to be modulated by a polymorphism in the serotonin gene-linked promoter region (5-HTTLPR). Little is known, however, about the persistence of this vulnerability across the life span, although clinical studies of adult populations suggest that gene-environment interaction may diminish with aging.

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