CORD BLOOD PLATELET LYSATE: IN VITRO EVALUATION TO SUPPORT THE USE IN REGENERATIVE MEDICINE. | Zendy

Caterina Giovanna Valentini | Zendy; Eugenia Rosa Nuzzolo | Zendy; Maria Bianchi | Zendy; Nicoletta Orlando | Zendy; Maria Grazia Iachininoto | Zendy; Priscilla Pinci | Zendy; Luciana Teofili | Zendy

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CORD BLOOD PLATELET LYSATE: IN VITRO EVALUATION TO SUPPORT THE USE IN REGENERATIVE MEDICINE.

Author(s) -

Caterina Giovanna Valentini,

Eugenia Rosa Nuzzolo,

Maria Bianchi,

Nicoletta Orlando,

Maria Grazia Iachininoto,

Priscilla Pinci,

Luciana Teofili

Publication year - 2019

Publication title -

mediterranean journal of hematology and infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 31

ISSN - 2035-3006

DOI - 10.4084/mjhid.2019.021

Subject(s) - medicine , regenerative medicine , cord blood , platelet , platelet lysate , in vitro , hematology , bioinformatics , intensive care medicine , stem cell , microbiology and biotechnology , biochemistry , biology , chemistry

Platelet-rich plasma (PRP) is an inexpensive and safe substitute of recombinant growth factors and . Due to its putative effect on tissue repair, the use of autologous PRP has become largely popular. Recently, a jellified PRP derivative obtained from umbilical cord blood (CB) has been utilized to treat mucosal and cutaneous lesions. Nevertheless, whether PRP derived from CB and adult blood display different potency in promoting cell growth has been rarely investigated. In this study, we compared cytokine profile and mesenchymal cell growth supporting the ability of platelet lysate obtained from adult and cord blood. Our results strongly back the utilization of CB platelet lysate , as an efficacious, safe and inexpensive alternative to promote damaged tissue healing when the autologous PRP is contraindicated. Moreover, the policy of manufacturing CB platelet lysate can limit the current disposal of many collected CB units not suitable for transplant due to their low nucleated cell count.

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